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Sermorelin vs Tesamorelin

Updated 13 sources

Key differences

  1. 1Tesamorelin is full-length GHRH(1-44) with a stabilizer. It is currently approved and has Phase 3 visceral-fat data. Sermorelin's approval is discontinued.
  2. 2Both are GHRH-based. Sermorelin is the 1-29 fragment and its approval was discontinued. Tesamorelin is full length and currently approved.

Side by side

Facts from each record, in the same words as their own pages.
Sermorelin and Tesamorelin side by side
SermorelinTesamorelin
Category
  • GH axis
  • GH axis
Evidence
  • Some human trials
  • Strong human trials
FDA status
  • Formerly approved as GerefRegulatory
  • FDA approved as Egrifta +2Regulatory
WADA
  • Prohibited
  • Prohibited
Half-life
  • Minutes. 10.4 minutes after IV dosing in rats, about 4.3 minutes in a review table, and 10 to 20 minutes per guides.Competitor guide
  • 8 minutes (Egrifta SV) and 11 minutes (Egrifta WR) in healthy subjects. Older figures for the original formulation are 26 to 38 minutes.Clinical study
Routes
  • Subcutaneous injection
  • Subcutaneous injection
Reported doses
  • 100 to 500 mcg (subcutaneous injection)
  • 1 to 2 mg (subcutaneous injection)
  • 125 to 1,000 mcg (subcutaneous injection)
Most cited frequency
  • Once daily at bedtime
  • Once daily
Vial sizes
  • 5 mg, 6 mg, 10 mgCompetitor guide
  • 2 mg, 5 mg, 10 mg, 20 mgCompetitor guide
Mixed vial keeps
  • Fridge, 2 to 8 °C.Competitor guide
  • Egrifta SV: use right after mixing and discard the rest.Competitor guide
Protocols on file
  • 11
  • 11

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

13 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory6

  1. Drugs@FDA Geref records (openFDA)FDA · checked Oct 23, 2026
  2. Egrifta SV labelDailyMed · checked Oct 23, 2026
  3. Egrifta WR labelDailyMed · checked Oct 23, 2026
  4. Determination that Geref was not withdrawn for safety or effectivenessFederal Register · checked Oct 23, 2026

Competitor guide3

  1. SermorelinPeptidesExplorer · checked Oct 23, 2026
  2. Sermorelin dosage guideBodyHackGuide · checked Oct 23, 2026
  3. Sermorelin dosage guidePeptideDeck · checked Oct 23, 2026