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Selank vs Semax

Updated 12 sources

Key differences

  1. 1Selank is built on tuftsin, an immune peptide. Semax is built on a fragment of the stress hormone ACTH. Both carry the same Pro-Gly-Pro tail.
  2. 2Selank slows the enzymes that break down enkephalins. Semax raises BDNF and its receptor in rodents.
  3. 3Users and guides frame Semax as the one that sharpens and Selank as the one that calms. Some report Semax raising heart rate or agitation while Selank settles them.
  4. 4Typical anecdotal use runs about 250 to 900 mcg a day for Selank versus 300 to 600 mcg for Semax. Semax's stroke regimen reaches 6,000 mcg a day.
  5. 5Semax is built on a fragment of ACTH, a stress hormone, and aimed at cognition and stroke. Selank is built on tuftsin, an immune peptide, and aimed at anxiety.
  6. 6Users frame Semax as focus and drive, Selank as calm and sleep.
  7. 7Both slow the enzymes that break down enkephalins in lab tests, at IC50 values of 10 and 20 microM.

Side by side

Facts from each record, in the same words as their own pages.
Selank and Semax side by side
SelankSemax
Category
  • Cognitive, Sleep
  • Cognitive
Evidence
  • Limited human data
  • Limited human data
FDA status
  • Not FDA approvedRegulatory
  • Not FDA approvedRegulatory
WADA
  • Not confirmed
  • Not confirmed
Half-life
  • Minutes. Per the Russian label, nasal Selank shows in plasma within 30 seconds and its level falls over 5 to 5.5 minutes. Nothing shows up in urine.Regulatory
  • No human data; FDA found no human pharmacokinetic studies. In rats, brain levels peak 2 minutes after a nasal dose and the peptide breaks down fast.Clinical study
Routes
  • Nasal, Subcutaneous injection
  • Nasal, Subcutaneous injection
Forms
  • Nasal spray, Vial (powder)
  • Nasal spray, Vial (powder)
Reported doses
  • 150 to 2,700 mcg (nasal)
  • 200 to 1,000 mcg (subcutaneous injection)
  • 150 to 6,000 mcg (nasal)
  • 12 to 18 mg (nasal)
  • 15 to 50 mcg/kg (nasal)
Most cited frequency
  • Once daily
  • Daily total
Vial sizes
  • 5 mg, 10 mg, 30 mgCompetitor guide
  • 5 mg, 10 mg, 20 mg, 30 mgCompetitor guide
Mixed vial keeps
  • Guides disagree on how long mixed Selank keeps: 2 to 3 weeks, 3 to 4 weeks, or 21 to 30 days.Competitor guide
  • Fridge at 2 to 8 C.Competitor guide
Protocols on file
  • 24
  • 30

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

12 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Reference work1

  1. SelankWikipedia · checked Oct 23, 2026

Competitor guide2

  1. Semax vs Selankbodyhackguide.co · checked Oct 23, 2026
  2. Selank vs Semaxpeptidedossier.com · checked Oct 23, 2026

Community-reported3

  1. Selank Results (comment)r/Peptides · checked Oct 23, 2026
  2. r/Peptides comment on Semaxr/Peptides · checked Oct 23, 2026
  3. r/Peptides comment on Semaxr/Peptides · checked Oct 23, 2026