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AOD-9604 vs HGH Fragment 176-191

Updated 11 sources

Key differences

  1. 1AOD-9604 is growth hormone residues 177 to 191 plus an added tyrosine at the front; Frag 176-191 is the unmodified tail segment. Sites mix up the two descriptions.
  2. 2AOD-9604 has a human safety dataset of about 900 people across six company trials. No controlled human trial of Frag 176-191 was found.
  3. 3WADA bans both by name.
  4. 4FDA describes AOD-9604 as hGH 177-191 with an added N-terminal tyrosine and a disulfide ring, 1,815.09 g/mol.
  5. 5Native hGH 176-191 starts with phenylalanine, yet some vials sold as Frag 176-191 list the tyrosine-first AOD-9604 sequence.
  6. 6AOD-9604 went through a company human trial program; no human trial of the fragment exists.

Side by side

Facts from each record, in the same words as their own pages.
AOD-9604 and HGH Fragment 176-191 side by side
AOD-9604HGH Fragment 176-191
Category
  • Weight loss
  • Weight loss, GH axis
Evidence
  • Limited human data
  • Animal data only
FDA status
  • Not FDA approvedRegulatory
  • Not FDA approvedRegulatory
WADA
  • Prohibited
  • Prohibited
Half-life
  • About 3 minutes after an IV bolus in pigs and about 4 minutes in rat blood in vitro. No human subcutaneous data.Clinical study
  • About 30 minutes, per guides; no measured value for the fragment.Competitor guide
  • 15 to 20 minutes, per another guide; also unsourced.Competitor guide
  • For the related AOD-9604: about 3 minutes after an IV dose in pigs, and 4 minutes in rat blood in a test tube.Regulatory
Routes
  • Oral, Subcutaneous injection
  • Subcutaneous injection
FormsNot reported
  • Vial (powder)
Reported doses
  • 0.25 to 30 mg (oral)
  • 250 to 500 mcg (subcutaneous injection)
  • 1 to 2 mg (subcutaneous injection)
  • 250 to 1,000 mcg (subcutaneous injection)
Most cited frequency
  • Once daily
  • Once daily, morning fasted
Vial sizes
  • 2 mg, 5 mg, 10 mgCompetitor guide
  • 2 mg, 5 mg, 10 mgCompetitor guide
Mixed vial keeps
  • Keep at 2 to 8 °C, away from light, and do not freeze and thaw.Community-reported
  • Fridge at 2 to 8 C, use within 14 to 21 days, do not freeze, keep from light.Competitor guide
Protocols on file
  • 12
  • 7

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

11 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory6

  1. FDA Evaluation of AOD-9604-Related Bulk Drug Substances (PCAC briefing, 11/5/2024)FDA · checked Oct 23, 2026
  2. WADA Prohibited List 2026 (Dutch Treaty Series trb-2026-25)officielebekendmakingen.nl · checked Oct 23, 2026
  3. WADA 2026 Prohibited ListWADA · checked Oct 24, 2026
  4. Final Summary Minutes, PCAC Meeting December 4, 2024FDA · checked Oct 24, 2026

Reference work1

  1. UniProt P01241, Somatotropin (Homo sapiens), sequenceUniProt · checked Oct 24, 2026

Vendor guide1

  1. HGH Fragment (176-191), catalog LT183171LifeTein (vendor product page) · checked Oct 24, 2026

Competitor guide2

  1. HGH Fragment 176-191: Dosage, Benefits & Safetypeptidesexplorer.com · checked Oct 24, 2026
  2. HGH Fragment 176-191 (HGH Frag)peptide-db.com · checked Oct 24, 2026