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HGH Fragment 176-191 vs Semaglutide

Updated 7 sources

Key differences

  1. 1Semaglutide works by cutting appetite and has large human trials; the fragment targets fat breakdown in theory and has none.
  2. 2Guides say the two can be combined because they act differently.

Side by side

Facts from each record, in the same words as their own pages.
HGH Fragment 176-191 and Semaglutide side by side
HGH Fragment 176-191Semaglutide
Category
  • Weight loss, GH axis
  • GLP-1, Weight loss
Evidence
  • Animal data only
  • Strong human trials
FDA status
  • Not FDA approvedRegulatory
  • FDA approved as Ozempic +2Regulatory
WADA
  • Prohibited
  • Not prohibited
Half-life
  • About 30 minutes, per guides; no measured value for the fragment.Competitor guide
  • 15 to 20 minutes, per another guide; also unsourced.Competitor guide
  • For the related AOD-9604: about 3 minutes after an IV dose in pigs, and 4 minutes in rat blood in a test tube.Regulatory
  • About 1 week. It is still present 5 to 7 weeks after the last dose.Regulatory
Routes
  • Subcutaneous injection
  • Subcutaneous injection, Oral
Forms
  • Vial (powder)
Not reported
Reported doses
  • 250 to 1,000 mcg (subcutaneous injection)
  • 0.125 to 7.2 mg (subcutaneous injection)
  • 1.5 to 25 mg (oral)
  • 300 to 1,000 mcg (subcutaneous injection)
Most cited frequency
  • Once daily, morning fasted
  • Once weekly; 4 weeks per step, then hold at 2.4 mg
Vial sizes
  • 2 mg, 5 mg, 10 mgCompetitor guide
  • 5 mg, 10 mg, 20 mg, 30 mgVendor guide
Mixed vial keeps
  • Fridge at 2 to 8 C, use within 14 to 21 days, do not freeze, keep from light.Competitor guide
  • Keep the mixed vial in the fridge and use it within about 28 days; one guide says 30.Competitor guide
Protocols on file
  • 7
  • 12

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

7 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Competitor guide2

  1. HGH Fragment 176-191: Dosage, Benefits & Safetypeptidesexplorer.com · checked Oct 24, 2026
  2. HGH Fragment 176-191 (HGH Frag)peptide-db.com · checked Oct 24, 2026