Skip to content

CagriSema vs Semaglutide

Updated 6 sources

Key differences

  1. 1REDEFINE 1 at 68 weeks: 22.7% weight loss on CagriSema vs 16.1% on semaglutide 2.4 mg if everyone adhered; 20.4% vs 14.9% counting everyone (treatment policy).
  2. 240.4% of CagriSema patients lost 25% or more of their weight vs 16.2% on semaglutide alone.
  3. 3Semaglutide alone is FDA approved (Wegovy, Ozempic); CagriSema is not.

Side by side

Facts from each record, in the same words as their own pages.
CagriSema and Semaglutide side by side
CagriSemaSemaglutide
Category
  • Weight loss, GLP-1
  • GLP-1, Weight loss
Evidence
  • Strong human trials
  • Strong human trials
FDA status
  • In clinical trialsRegulatory
  • FDA approved as Ozempic +2Regulatory
WADA
  • Not confirmed
  • Not prohibited
Half-life
  • Cagrilintide component: 159 to 195 hours, peaking 24 to 72 hours after a dose (phase 1b, given with semaglutide).Clinical study
  • Semaglutide component: 145 to 165 hours, peaking 12 to 24 hours after a dose (same trial).Clinical study
  • About 1 week. It is still present 5 to 7 weeks after the last dose.Regulatory
Routes
  • Subcutaneous injection
  • Subcutaneous injection, Oral
Forms
  • Vial (powder)
Not reported
Reported doses
  • 0.16 to 4.5 mg (subcutaneous injection)
  • 0.125 to 7.2 mg (subcutaneous injection)
  • 1.5 to 25 mg (oral)
  • 300 to 1,000 mcg (subcutaneous injection)
Most cited frequency
  • Once weekly, cagrilintide and semaglutide at the same mg (2.4 mg + 2.4 mg at maintenance)
  • Once weekly; 4 weeks per step, then hold at 2.4 mg
Vial sizes
  • 5 mg, 10 mg, 20 mgVendor guide
  • 5 mg, 10 mg, 20 mg, 30 mgVendor guide
Mixed vial keeps
  • Fridge at 2 to 8 °C, use within 30 days.Vendor guide
  • Keep the mixed vial in the fridge and use it within about 28 days; one guide says 30.Competitor guide
Protocols on file
  • 6
  • 12

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

6 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory4

  1. Ozempic Prescribing Information (rev. 01/2025)FDA · checked Oct 23, 2026
  2. Wegovy injection and tablets label (SPL v19, Jun 30 2026)DailyMed · checked Oct 24, 2026
  3. openFDA Drugs@FDA query for cagrilintideFDA (openFDA) · checked Oct 24, 2026
  4. NCT05567796 (REDEFINE 1), phase 3, active not recruitingClinicalTrials.gov · checked Oct 24, 2026