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PE-22-28 vs Semax

Updated 5 sources

Key differences

  1. 1Semax has a Russian drug label and human trials; PE-22-28 has only mouse data.
  2. 2PE-22-28 is used mainly for mood, Semax mainly for focus and BDNF. They are often stacked.

Side by side

Facts from each record, in the same words as their own pages.
PE-22-28 and Semax side by side
PE-22-28Semax
Category
  • Cognitive
  • Cognitive
Evidence
  • Animal data only
  • Limited human data
FDA status
  • Not FDA approvedRegulatory
  • Not FDA approvedRegulatory
WADA
  • Not confirmed
  • Not confirmed
Half-life
  • Not published. Described as relatively short in serum in vitro; the 23 hour effect half-time often quoted belongs to modified analogs in mice.Clinical study
  • No human data; FDA found no human pharmacokinetic studies. In rats, brain levels peak 2 minutes after a nasal dose and the peptide breaks down fast.Clinical study
Routes
  • Nasal, Subcutaneous injection
  • Nasal, Subcutaneous injection
Forms
  • Vial (powder), Nasal spray
  • Nasal spray, Vial (powder)
Reported doses
  • 100 to 500 mcg (nasal)
  • 50 to 500 mcg (subcutaneous injection)
  • 150 to 6,000 mcg (nasal)
  • 12 to 18 mg (nasal)
  • 15 to 50 mcg/kg (nasal)
Most cited frequency
  • Once daily, in the morning
  • Once daily
Vial sizes
  • 8 mg, 10 mg, 20 mgVendor guide
  • 5 mg, 10 mg, 20 mg, 30 mgCompetitor guide
Mixed vial keeps
  • Fridge at 2 to 8 C, away from light.Competitor guide
  • Fridge at 2 to 8 C.Competitor guide
Protocols on file
  • 8
  • 30

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

5 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.