Semaglutide vs Survodutide

Name: Semaglutide vs Survodutide
Published: 2026-10-24

Updated Oct 24, 20266 sources

Key differences

1Semaglutide is GLP-1 only. Survodutide adds glucagon receptor activity aimed at liver fat and energy use.
2In a 16-week type 2 diabetes trial, survodutide at 1.8 mg weekly or more cut more weight than open-label semaglutide 1.0 mg, which gave 5.3%.
3Semaglutide is FDA approved (Ozempic, Wegovy). Survodutide is investigational.

Facts from each record, in the same words as their own pages.

Semaglutide and Survodutide side by side
	Semaglutide	Survodutide
Category	GLP-1, Weight loss	GLP-1, Weight loss
Evidence	Strong human trials	Strong human trials
FDA status	FDA approved as Ozempic +2Regulatory	In clinical trialsRegulatory
WADA	Not prohibited	Not confirmed
Half-life	About 1 week. It is still present 5 to 7 weeks after the last dose.Regulatory	About 6 to 7 days, an estimate from one guide. We found no published human half-life figure.Competitor guide
Routes	Subcutaneous injection, Oral	Subcutaneous injection
Forms	Not reported	Vial (powder), Other form
Reported doses	0.125 to 7.2 mg (subcutaneous injection) 1.5 to 25 mg (oral) 300 to 1,000 mcg (subcutaneous injection)	0.3 to 6 mg (subcutaneous injection)
Most cited frequency	Once weekly; 4 weeks per step, then hold at 2.4 mg	Once weekly, stepped up to a target of 3.6 or 6.0 mg, then held to week 76
Vial sizes	5 mg, 10 mg, 20 mg, 30 mgVendor guide	5 mg, 6 mg, 10 mg, 20 mgCompetitor guide
Mixed vial keeps	Keep the mixed vial in the fridge and use it within about 28 days; one guide says 30.Competitor guide	Keep the mixed vial in the fridge at 2 to 8 C, away from light, and do not freeze and thaw it.Competitor guide
Protocols on file	12	10

Doses shown are what sources report, labelled by origin. Not medical advice.

6 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.