Sermorelin vs Somatropin (HGH)

Name: Sermorelin vs Somatropin (HGH)
Published: 2026-10-24

Updated Oct 24, 202613 sources

Key differences

1Sermorelin's FDA approval (Geref) was withdrawn in 2009 and it is now compounded; somatropin brands remain approved.
2Sermorelin triggers your own GH; somatropin replaces it.

Facts from each record, in the same words as their own pages.

Sermorelin and Somatropin (HGH) side by side
	Sermorelin	Somatropin (HGH)
Category	GH axis	GH axis
Evidence	Some human trials	Strong human trials
FDA status	Formerly approved as GerefRegulatory	FDA approved as Genotropin +7Regulatory
WADA	Prohibited	Prohibited
Half-life	Minutes. 10.4 minutes after IV dosing in rats, about 4.3 minutes in a review table, and 10 to 20 minutes per guides.Competitor guide	About 3 hours after a subcutaneous dose in adults with GH deficiency; 0.4 hours when given IV. The longer SC figure reflects slow absorption.Regulatory 3.8 hours after a subcutaneous dose in healthy adults (Humatrope).Regulatory 2.5 to 2.8 hours after a subcutaneous dose in healthy adults (Omnitrope).Regulatory
Routes	Subcutaneous injection	Subcutaneous injection
Forms	Not reported	Vial (powder), Prefilled pen
Reported doses	100 to 500 mcg (subcutaneous injection)	0.15 to 0.3 mg (subcutaneous injection) 0.004 to 0.1 mg/kg (subcutaneous injection) 1 to 8 IU (subcutaneous injection)
Most cited frequency	Once daily at bedtime	Once daily; raise by about 0.1 to 0.2 mg/day every 1 to 2 months
Vial sizes	5 mg, 6 mg, 10 mgCompetitor guide	5.8 mg, 5 mg, 10 mg, 4 IU, 10 IU, 12 IURegulatory
Mixed vial keeps	Fridge, 2 to 8 °C.Competitor guide	Genotropin cartridge after mixing: fridge at 2 to 8 C for up to 28 days, protected from light.Regulatory
Protocols on file	11	10

Doses shown are what sources report, labelled by origin. Not medical advice.

13 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.